by Mark Lasbury in As Many Exceptions As Rules
The three wise men made a gift of myrrh, knowing it was an important incense, embalming agent, and anti-microbial. What they didn’t know is that 2000 years later we would find that constituents of myrrh would be important in curing cancer.... Read more »
Xu, H., Xu, L., Li, L., Fu, J., & Mao, X. (2012) Reversion of P-glycoprotein-mediated multidrug resistance by guggulsterone in multidrug-resistant human cancer cell lines. European Journal of Pharmacology, 694(1-3), 39-44. DOI: 10.1016/j.ejphar.2012.06.046
Wang, W., Uen, Y., Chang, M., Cheah, K., Li, J., Yu, W., Lee, K., Choy, C., & Hu, C. (2012) Protective effect of guggulsterone against cardiomyocyte injury induced by doxorubicin in vitro. BMC Complementary and Alternative Medicine, 12(1), 138. DOI: 10.1186/1472-6882-12-138
de Rapper, S., Van Vuuren, S., Kamatou, G., Viljoen, A., & Dagne, E. (2012) The additive and synergistic antimicrobial effects of select frankincense and myrrh oils - a combination from the pharaonic pharmacopoeia. Letters in Applied Microbiology, 54(4), 352-358. DOI: 10.1111/j.1472-765X.2012.03216.x
by Mark Lasbury in As Many Exceptions As Rules
Your Christmas tree can kill you, but it can also save your life. The same holds true for mistletoe, ivy, and holly. Each is toxic, but each has uses in medicine. The least toxic Christmas plant is the most often thought of as poisonous – poinsettias really aren’t that bad, kids would have to eat 500 leaves to bring on the nastiest effects.... Read more »
Liu, B., Zhou, J., Li, Y., Zou, X., Wu, J., Gu, J., Yuan, J., Zhao, B., Feng, L., Jia, X.... (2014) Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway. BMC Complementary and Alternative Medicine, 14(1), 412. DOI: 10.1186/1472-6882-14-412
Tröger W, Galun D, Reif M, Schumann A, Stanković N, & Milićević M. (2014) Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Deutsches Arzteblatt international, 111(29-30), 493. PMID: 25142075
Tsui, K., Wang, J., Wu, L., & Chiu, C. (2012) Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-Based Complementary and Alternative Medicine, 1-12. DOI: 10.1155/2012/190107
Earl, E., Altaf, M., Murikoli, R., Swift, S., & O'Toole, R. (2010) Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis. BMC Complementary and Alternative Medicine, 10(1), 25. DOI: 10.1186/1472-6882-10-25
by Wiley Asia Blog in Wiley Asia Blog - Social Science
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but that animal research could provide valuable clues to their causes.
Writing in the British Journal of Pharmacology, Dr David Slatt........ Read more »
Perani, C., & Slattery, D. (2014) Using animal models to study post-partum psychiatric disorders. British Journal of Pharmacology, 171(20), 4539-4555. DOI: 10.1111/bph.12640
by Mark E. Lasbury in The 'Scope
Your body has several mechanisms to protect you from the cold – and some are just plain weird. You can trap air next to your body just like when your cat hisses and all his fur stands on end. Adults can shiver, but babies can generate heat without shivering. What’s more, adults can learn to act like babies - it will help them stay warm and lose weight!... Read more »
Torkamani, N., Jones, L., Rufaut, N., & Sinclair, R. (2014) Beyond goosebumps: Does the arrector pili muscle have a role in hair loss?. International Journal of Trichology, 6(3), 88. DOI: 10.4103/0974-7753.139077
Jiménez-Aranda, A., Fernández-Vázquez, G., Campos, D., Tassi, M., Velasco-Perez, L., Tan, D., Reiter, R., & Agil, A. (2013) Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. Journal of Pineal Research. DOI: 10.1111/jpi.12089
Lim, S., Honek, J., Xue, Y., Seki, T., Cao, Z., Andersson, P., Yang, X., Hosaka, K., & Cao, Y. (2012) Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nature Protocols, 7(3), 606-615. DOI: 10.1038/nprot.2012.013
Bi, S., & Li, L. (2013) Browning of white adipose tissue: role of hypothalamic signaling. Annals of the New York Academy of Sciences, 1302(1), 30-34. DOI: 10.1111/nyas.12258
by Mark E. Lasbury in The 'Scope
Your body has several mechanisms to protect you from the cold – and some are just plain weird. You can trap air next to your body just like when your cat hisses and all his fur stands on end. Adults can shiver, but babies can generate heat without shivering. What’s more, adults can learn to act like babies - it will help them stay warm and lose weight!... Read more »
Torkamani, N., Jones, L., Rufaut, N., & Sinclair, R. (2014) Beyond goosebumps: Does the arrector pili muscle have a role in hair loss?. International Journal of Trichology, 6(3), 88. DOI: 10.4103/0974-7753.139077
Jiménez-Aranda, A., Fernández-Vázquez, G., Campos, D., Tassi, M., Velasco-Perez, L., Tan, D., Reiter, R., & Agil, A. (2013) Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. Journal of Pineal Research. DOI: 10.1111/jpi.12089
Lim, S., Honek, J., Xue, Y., Seki, T., Cao, Z., Andersson, P., Yang, X., Hosaka, K., & Cao, Y. (2012) Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nature Protocols, 7(3), 606-615. DOI: 10.1038/nprot.2012.013
Bi, S., & Li, L. (2013) Browning of white adipose tissue: role of hypothalamic signaling. Annals of the New York Academy of Sciences, 1302(1), 30-34. DOI: 10.1111/nyas.12258
by Mark E. Lasbury in The 'Scope
Everyone knows that you can dies from being out in the cold for too long, but do you how the cold can bring about your demise? It has to do with water, electricity, and believe it or not, stripping.... Read more »
Palmers PJ, Hiltrop N, Ameloot K, Timmermans P, Ferdinande B, Sinnaeve P, Nieuwendijk R, & Malbrain ML. (2014) From therapeutic hypothermia towards targeted temperature management: a decade of evolution. Anaesthesiology intensive therapy. PMID: 25421924
Argacha, J., Adamopoulos, D., Gujic, M., Fontaine, D., Amyai, N., Berkenboom, G., & van de Borne, P. (2008) Acute Effects of Passive Smoking on Peripheral Vascular Function. Hypertension, 51(6), 1506-1511. DOI: 10.1161/HYPERTENSIONAHA.107.104059
Adams MD, Earnhardt JT, Dewey WL, & Harris LS. (1976) Vasoconstrictor actions of delta8- and delta9-tetrahydrocannabinol in the rat. The Journal of pharmacology and experimental therapeutics, 196(3), 649-56. PMID: 4606
Morioka C, Kondo H, Akashi K, Matsumura K, Ochi N, Makinaga G, & Furukawa T. (1997) The continuous and simultaneous blood flow velocity measurement of four cerebral vessels and a peripheral vessel during cigarette smoking. Psychopharmacology, 131(3), 220-9. PMID: 9203232
by Christen Rune Stensvold in Blastocystis Parasite Blog
A few notes on deliberate and inadvertent attempts to eradicate Blastocystis.... Read more »
Nagel R, Bielefeldt-Ohmann H, & Traub R. (2014) Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients. Gut pathogens, 34. PMID: 25349629
by Mark Lasbury in The 'Scope
What is tryptophan, and is it indeed responsible for the snoring that follows Thanksgiving dinner? ... Read more »
Russo, E., Scicchitano, F., Citraro, R., Aiello, R., Camastra, C., Mainardi, P., Chimirri, S., Perucca, E., Donato, G., & De Sarro, G. (2012) Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience, 282-288. DOI: 10.1016/j.neuroscience.2012.09.021
Bruce KR, Steiger H, Young SN, Kin NM, Israël M, & Lévesque M. (2009) Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women. Journal of psychiatry , 34(5), 376-82. PMID: 19721848
by William Yates, M.D. in Brain Posts
Clinicians treating patients with eating disorders find the challenge great with many treatment-resistant cases.To some extent, this is true of any clinical disorder. Outpatient treatment rolls and inpatient samples are over-represented by those failing to respond to initial interventions.A medical example is helpful here. Endocrinologists specializing in diabetes see more complicated cases where glucose control is difficult and diabetic complications are common.Diabetics with easy glucose contr........ Read more »
Halmi, K. (2013) Perplexities of treatment resistence in eating disorders. BMC Psychiatry, 13(1), 292. DOI: 10.1186/1471-244X-13-292
by Mark Lasbury in As Many Exceptions As Rules
Tryptophan supposedly puts you to sleep at Thanksgiving, but research shows that turkey isn’t really that high in this amino acid. On the other hand, tryptophan can save lives. In several old cultures, human sacrifices increased during periods of the year when tryptophan levels in the diet were low. ... Read more »
Musil, R., Zill, P., Seemüller, F., Bondy, B., Meyer, S., Spellmann, I., Bender, W., Adli, M., Heuser, I., Fisher, R.... (2012) Genetics of emergent suicidality during antidepressive treatment—Data from a naturalistic study on a large sample of inpatients with a major depressive episode. European Neuropsychopharmacology. DOI: 10.1016/j.euroneuro.2012.08.009
Russo, E., Scicchitano, F., Citraro, R., Aiello, R., Camastra, C., Mainardi, P., Chimirri, S., Perucca, E., Donato, G., & De Sarro, G. (2012) Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience, 282-288. DOI: 10.1016/j.neuroscience.2012.09.021
by Mark E. Lasbury in The 'Scope
There are more than 100 drug commercials on TV every hour of every day. Why? Because they work. Research shows that advertised drugs are prescribed 9x more than comparable drugs that aren’t advertised. And all those side effect notices? The drug companies like them because research says that all you remember is that they were “honest” with you.... Read more »
Faerber, A., & Kreling, D. (2013) Content Analysis of False and Misleading Claims in Television Advertising for Prescription and Nonprescription Drugs. Journal of General Internal Medicine, 29(1), 110-118. DOI: 10.1007/s11606-013-2604-0
Steinhart, Y., Carmon, Z., & Trope, Y. (2013) Warnings of Adverse Side Effects Can Backfire Over Time. Psychological Science, 24(9), 1842-1847. DOI: 10.1177/0956797613478948
Corrigan, P., Kosyluk, K., Konadu Fokuo, J., & Park, J. (2014) How Does Direct to Consumer Advertising Affect the Stigma of Mental Illness?. Community Mental Health Journal, 50(7), 792-799. DOI: 10.1007/s10597-014-9698-7
by Mark Lasbury in As Many Exceptions As Rules
The cornucopia is a symbol for unending bounty, and has become a synonym for Thanksgiving in the US. But what if we investigate this further; the goat should be the real symbol for Thanksgiving. It spawned the horn of plenty in Greek mythology, it represents a dairy and meat source that the pilgrims made use of. And as far as a sustainable source of red meat, its tops. Goat – the other green meat!... Read more »
O'Callaghan YC, O'Brien NM, Kenny O, Harrington T, Brunton N, & Smyth TJ. (2014) Anti-Inflammatory Effects of Wild Irish Mushroom Extracts in RAW264.7 Mouse Macrophage Cells. Journal of medicinal food. PMID: 25136763
Liu YT, Sun J, Luo ZY, Rao SQ, Su YJ, Xu RR, & Yang YJ. (2012) Chemical composition of five wild edible mushrooms collected from Southwest China and their antihyperglycemic and antioxidant activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(5), 1238-44. PMID: 22300772
by Mark Lasbury in As Many Exceptions As Rules
Animal-like protists are similar to animal cells, but they do many things in their single cell that we have a hard time competing with. New research shows that they may be useful in medicine, as well as lethal in some cases. N. fowleri is a brain eating amoeba, but calcium tests of foraminifera may be helpful in bone grafts and repairing skull fractures.... Read more »
Jack, R., Garrod, O., & Schyns, P. (2014) Dynamic Facial Expressions of Emotion Transmit an Evolving Hierarchy of Signals over Time. Current Biology, 24(2), 187-192. DOI: 10.1016/j.cub.2013.11.064
Dhawan S, Jain D, & Mehta VS. (2013) Balantidium coli: an unrecognized cause of vertebral osteomyelitis and myelopathy. Journal of neurosurgery. Spine, 18(3), 310-3. PMID: 23259539
Chou J, Hao J, Kuroda S, Ben-Nissan B, Milthopre B, & Otsuka M. (2014) Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres. Journal of tissue engineering, 2147483647. PMID: 24808939
Yuasa T, & Takahashi O. (2014) Ultrastructural morphology of the reproductive swarmers of Sphaerozoum punctatum (Huxley) from the East China Sea. European journal of protistology, 50(2), 194-204. PMID: 24447698
Sifuentes LY, Choate BL, Gerba CP, & Bright KR. (2014) The occurrence of Naegleria fowleri in recreational waters in Arizona. Journal of environmental science and health. Part A, Toxic/hazardous substances , 49(11), 1322-30. PMID: 24967566
Mah JL, Christensen-Dalsgaard KK, & Leys SP. (2014) Choanoflagellate and choanocyte collar-flagellar systems and the assumption of homology. Evolution , 16(1), 25-37. PMID: 24393465
by Christen Rune Stensvold in Blastocystis Parasite Blog
October was mostly about conferences and funding. And why is no one studying endosymbiosis in Blastocystis?... Read more »
Fletcher S, Caprarelli G, Merif J, Andresen D, Hal SV, Stark D, & Ellis J. (2014) Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia. Journal of public health research, 3(2), 298. PMID: 25343139
Nagel R, Bielefeldt-Ohmann H, & Traub R. (2014) Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients. Gut pathogens, 34. PMID: 25349629
Nowack EC, & Melkonian M. (2010) Endosymbiotic associations within protists. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365(1541), 699-712. PMID: 20124339
Prodeus TV, Zelia OP, Khlebnikova TA, & Pikul' DA. (2014) [Extraenteric infection caused by Blastocystis spp. in a female patient with liver abscess]. Meditsinskaia parazitologiia i parazitarnye bolezni, 6-9. PMID: 25296418
by Mark Lasbury in As Many Exceptions As Rules
Halloween conjures up monsters, like Mary Shelly’s Frankenstein. Her story is just as applicable for us today – the story of science being responsible for what it creates. The so-called Frankenfoods are called dangerous – but why? Studies that label them dangerous have been retracted or are merely correlative. New studies have shown that genetically modified crops are safe for livestock and humans. However, there are valid concerns, so every GMO must be tested rigorously.... Read more »
Goldstein, D. (2014) Tempest in a Tea Pot: How did the Public Conversation on Genetically Modified Crops Drift so far from the Facts?. Journal of Medical Toxicology, 10(2), 194-201. DOI: 10.1007/s13181-014-0402-7
Tufarelli V, & Laudadio V. (2013) Genetically Modified Feeds in Poultry Diet: Safety, Performance and Product Quality. Critical reviews in food science and nutrition. PMID: 24915369
Van Eenennaam AL, & Young AE. (2014) Prevalence and impacts of genetically engineered feedstuffs on livestock populations. Journal of animal science, 92(10), 4255-78. PMID: 25184846
Snell C, Bernheim A, Bergé JB, Kuntz M, Pascal G, Paris A, & Ricroch AE. (2012) Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1134-48. PMID: 22155268
McCall WV, Andrade C, & Sienaert P. (2014) Searching for the mechanism(s) of ECT's therapeutic effect. The journal of ECT, 30(2), 87-9. PMID: 24755719
by William Yates, M.D. in Brain Posts
The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »
Cerqueira CT, Sato JR, de Almeida JR, Amaro E Jr, Leite CC, Gorenstein C, Gentil V, & Busatto GF. (2014) Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions. Translational psychiatry. PMID: 24984192
by Mark Lasbury in As Many Exceptions As Rules
Bacteria can swarm to conquer new territory or settle into structured biofilms, not unlike tribes that are nomadic versus those that build cities. New research indicates has shed light on the mechanics of swarming and biofilm production, including the function of extracellular DNA and secreted polysaccharides. Both biofilms and swarming depend on quorum sensing, and several new papers have identified chemicals that can interrupt quorum sensing in pathogenic bacteria and therefore prevent disease........ Read more »
Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR.... (2013) Self-organization of bacterial biofilms is facilitated by extracellular DNA. Proceedings of the National Academy of Sciences of the United States of America, 110(28), 11541-6. PMID: 23798445
Deng P, de Vargas Roditi L, van Ditmarsch D, & Xavier JB. (2014) The ecological basis of morphogenesis: branching patterns in swarming colonies of bacteria. New journal of physics, 15006-15006. PMID: 24587694
McCall J, Hidalgo G, Asadishad B, & Tufenkji N. (2013) Cranberry impairs selected behaviors essential for virulence in Proteus mirabilis HI4320. Canadian journal of microbiology, 59(6), 430-6. PMID: 23750959
Alteri CJ, Himpsl SD, Pickens SR, Lindner JR, Zora JS, Miller JE, Arno PD, Straight SW, & Mobley HL. (2013) Multicellular bacteria deploy the type VI secretion system to preemptively strike neighboring cells. PLoS pathogens, 9(9). PMID: 24039579
by Rogue Medic in Rogue Medic
We like to give treatments that produce results that we can see and logically attribute to the treatments we gave.
We like to give IV (IntaVenous) furosemide (Lasix – frusemide in Commonwealth countries) for CHF (Congestive Heart Failure).
1. The patient had CHF.
2. I gave IV furosemide.
3. The patient produced urine.... Read more »
Figueras J, & Weil MH. (1978) Blood volume prior to and following treatment of acute cardiogenic pulmonary edema. Circulation, 57(2), 349-55. PMID: 618625
Francis GS, Siegel RM, Goldsmith SR, Olivari MT, Levine TB, & Cohn JN. (1985) Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis. Annals of internal medicine, 103(1), 1-6. PMID: 2860833
Hoffman JR, & Reynolds S. (1987) Comparison of nitroglycerin, morphine and furosemide in treatment of presumed pre-hospital pulmonary edema. Chest, 92(4), 586-93. PMID: 3115687
by Mark E. Lasbury in The 'Scope
Betting on American football and football proper is a trillion dollar a year industry. Why do only 4% of gamblers become addicted. Some of it is actually due to the games themselves. New research is showing that a belief in your knowledge of the game and the “near miss” wherein you almost win your bet, are strong factors in dopamine signaling in the reward centers of the brain.... Read more »
Anselme P, & Robinson MJ. (2013) What motivates gambling behavior? Insight into dopamine's role. Frontiers in behavioral neuroscience, 182. PMID: 24348355
Huberfeld R, Gersner R, Rosenberg O, Kotler M, & Dannon PN. (2013) Football gambling three arm-controlled study: gamblers, amateurs and laypersons. Psychopathology, 46(1), 28-33. PMID: 22890307
Khazaal Y, Chatton A, Billieux J, Bizzini L, Monney G, Fresard E, Thorens G, Bondolfi G, El-Guebaly N, Zullino D.... (2012) Effects of expertise on football betting. Substance abuse treatment, prevention, and policy, 18. PMID: 22578101
Zhou K, Tang H, Sun Y, Huang GH, Rao LL, Liang ZY, & Li S. (2012) Belief in luck or in skill: which locks people into gambling?. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming, 28(3), 379-91. PMID: 21894576
Grötsch P, Lange C, Wiesbeck GA, & Lang U. (2013) Pathological Gambling Induced by Dopamine Antagonists: A Case Report. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming. PMID: 24356928
by The Neurocritic in The Neurocritic
Bibimbop Brugmansia ** Do NOT try this at home.Edible flowers can make for a beautiful garnish on salads and trendy Brooklyn cocktails, but those decorative flourishes can be a disaster for the oblivious amateur. An unusual case report in BMC Research Notes summarizes what happens when you sprinkle toxic flower petals on your bibimbop (Kim et al., 2014).A 64 year old Koren woman came to the emergency room with incoherent speech and fluctuations in attention, orientation and comprehension. She ha........ Read more »
Isbister, G., Oakley, P., Dawson, A., & Whyte, I. (2003) Presumed Angel's trumpet (Brugmansia) poisoning: Clinical effects and epidemiology. Emergency Medicine Australasia, 15(4), 376-382. DOI: 10.1046/j.1442-2026.2003.00477.x
Kim, Y., Kim, J., Kim, O., & Kim, W. (2014) Intoxication by angel’s trumpet: case report and literature review. BMC Research Notes, 7(1), 553. DOI: 10.1186/1756-0500-7-553
Evans Schultes, R., & Plowman, T. (1979) The ethnobotany of Brugmansia. Journal of Ethnopharmacology, 1(2), 147-164. DOI: 10.1016/0378-8741(79)90004-7
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