All posts; Tags Include "Clinical Research"
- April 12, 2016
- 05:00 PM
- 286 views
Dr. Kudenchuk is Misrepresenting ALPS as 'Significant'
by Rogue Medic in Rogue Medic
This study was very well done, but it was not designed to provide valid information about the effects of amiodarone or lidocaine on witnessed arrests or on EMS Witnessed arrests. Maybe the authors were overconfident.
In resuscitation research, we have abundant evidence that overconfidence is much more common than improvements in outcomes.... Read more »
Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204
Glover BM, Brown SP, Morrison L, Davis D, Kudenchuk PJ, Van Ottingham L, Vaillancourt C, Cheskes S, Atkins DL, Dorian P.... (2012) Wide variability in drug use in out-of-hospital cardiac arrest: A report from the resuscitation outcomes consortium. Resuscitation. PMID: 22858552
- April 6, 2016
- 12:02 PM
- 143 views
World Serology Bank: Key to a Better Understanding of Infectious Disease Dynamics?
by Pranab Chatterjee in Zoonoticus
An article published in The Lancet today has highlighted the possibility of establishing a World Serology Bank to better understand the dynamics of infectious disease dynamics, especially in an era where vaccinations against infectious diseases is becoming more and more prevalent. With rapid advance in diagnostic technologies, there has been impressive progress in what used […]... Read more »
Metcalf, C., Farrar, J., Cutts, F., Basta, N., Graham, A., Lessler, J., Ferguson, N., Burke, D., & Grenfell, B. (2016) Use of serological surveys to generate key insights into the changing global landscape of infectious disease. The Lancet. DOI: 10.1016/S0140-6736(16)30164-7
- April 4, 2016
- 06:15 PM
- 314 views
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
by Rogue Medic in Rogue Medic
I wrote about the start of the ALPS (Amiodarone, Lidocaine, Placebo Study) in 2012[1] and the results are now in.
... Read more »
Kudenchuk, P., Brown, S., Daya, M., Rea, T., Nichol, G., Morrison, L., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. New England Journal of Medicine. DOI: 10.1056/NEJMoa1514204
- March 11, 2016
- 08:26 AM
- 367 views
Kill "Bill" !!!
by AG McCluskey in Zongo's Cancer Diaries
Drug Discovery, Part I
How does Drug Discovery start? How are targets identified? Time for Epidemiology 101... Read more »
Lu, Y., Guan, G., Chen, J., Hu, B., Sun, C., Ma, Q., Wen, Y., Qiu, X., & Zhou, Y. (2015) Aberrant CXCR4 and β-catenin expression in osteosarcoma correlates with patient survival. Oncology Letters. DOI: 10.3892/ol.2015.3535
AG McCluskey. (2016) Kill "Bill". Zongo's Cancer Diaries. info:/
- February 12, 2016
- 04:16 AM
- 360 views
Maintained disomic chromosome 17 as a diagnostic marker for BHD-associated chromophobe RCC
by Danielle Stevenson in BHD Research Blog
Renal cell carcinomas (RCCs) can be life-threatening and although mostly sporadic, approximately 5% are associated with genetic conditions such as BHD. Early identification of families carrying cancer-predisposing mutations enables access to regular screening and earlier treatment. However, it can be difficult to distinguish between sporadic and inherited RCC based on standard immunohistological analysis. New research from Kato et al. (2016) assessed whether variability in the chromosomal status........ Read more »
Kato, I., Iribe, Y., Nagashima, Y., Kuroda, N., Tanaka, R., Nakatani, Y., Hasumi, H., Yao, M., & Furuya, M. (2016) Fluorescent and Chromogenic in situ Hybridization of CEN17q as a Potent Useful Diagnostic Marker for Birt-Hogg-Dubé Syndrome-associated Chromophobe Renal Cell Carcinomas. Human Pathology. DOI: 10.1016/j.humpath.2016.01.004
- January 24, 2016
- 02:45 PM
- 374 views
Treat the pain... or treat the depression? Carpal Tunnel Syndrome management
by Bronwyn Thompson in Healthskills: Skills for Healthy Living
Carpal tunnel syndrome is a very common pain disorder associated with compression of the median nerve at the carpal tunnel. Approximately 139 women and 67 males per 100,000 people will report this problem over the course of one year, although this depends on the definition used. The problem with CTS is not only that it is common, but also that it affects function - it is really difficult to carry out normal daily life with a numb or tingly hand, poor grip strength (particularly in the fingertips........ Read more »
Fernández-Muñoz, J., Palacios-Ceña, M., Cigarán-Méndez, M., Ortega-Santiago, R., de-la-Llave-Rincón, A., Salom-Moreno, J., & Fernández-de-las-Peñas, C. (2016) Pain is Associated to Clinical, Psychological, Physical, and Neurophysiological Variables in Women With Carpal Tunnel Syndrome. The Clinical Journal of Pain, 32(2), 122-129. DOI: 10.1097/AJP.0000000000000241
- January 15, 2016
- 09:07 AM
- 347 views
A Weighty Problem……
by anthony.mccluskey12 in Zongo's Cancer Diaries
Amid all of the hoopla that accompanied last week’s press reports about the new Alcohol Consumption Guidelines, something else slipped under the radar. CRUK released a statement, which didn’t receive quite the same level of media hysteria. Which is surprising, frankly, because it involved another popular subject. One which, if it had been released at […]... Read more »
Pérez-Hernández,A.I., Catalán, V., Gómez-Ambrosi, J., AmaiaRodríguez, A., & Frühbeck, G. (2014) Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Frontiers in Endocrinology. DOI: 10.3389/fendo.2014.00065
Bhimjiyani, A., Knuchel-Takano, A., & Hunt, D. (2016) Tipping the scales: Why preventing obesity makes economic sense. CRUK. info:/
- January 15, 2016
- 09:04 AM
- 358 views
A Weighty Problem....
by AG McCluskey in Zongo's Cancer Diaries
Obesity causes many medical conditions, such as Heart Disease, Stroke & Diabetes.
.....And cancer....?... Read more »
Pérez-Hernández,A.I., Catalán, V., Gómez-Ambrosi, J., AmaiaRodríguez, A., & Frühbeck, G. (2014) Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion. Frontiers in Endocrinology. DOI: 10.3389/fendo.2014.00065
Bhimjiyani, A., Knuchel-Takano, A., & Hunt, D. (2016) Tipping the scales: Why preventing obesity makes economic sense. CRUK. info:/
- January 9, 2016
- 03:36 PM
- 499 views
Turning to the “Infected Jelly” to Treat Ebola
by Pranab Chatterjee in Scepticemia
The NEJM has come out with a very interesting paper: Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The explosive outbreak of Ebola Virus Disease in West Africa last year had hijacked the headlines and media space in a big way. Multiple solutions were touted, including the vaccine trial STRIVE. Few articles, however, looked…... Read more »
van Griensven J, Edwards T, de Lamballerie X, Semple MG, Gallian P, Baize S, Horby PW, Raoul H, Magassouba N, Antierens A.... (2016) Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea. The New England journal of medicine, 374(1), 33-42. PMID: 26735992
- January 9, 2016
- 01:28 PM
- 677 views
If Colistin Goes, Can Carbapenems be Far Behind?
by Pranab Chatterjee in Scepticemia
I wrote about the disaster-in-the-making discovery of transmissible resistance to colistin, a last resort antibiotic, when the Lancet Infectious Diseases published a paper based on data coming out from surveillance in China. At that point of time, the isolation of the transmissible gene providing resistance (mcr1 gene) gained a lot of attention. Maryn McKenna’s blog post went…... Read more »
Poirel, L., Kieffer, N., Liassine, N., Thanh, D., & Nordmann, P. (2016) Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(16)00006-2
- January 5, 2016
- 11:37 AM
- 460 views
Stroke Risk Following Mental Disorders
by William Yates, M.D. in Brain Posts
An important recent manuscript published in JAMA Psychiatry looked at medical illnesses rates following diagnosis of a brain (mental) disorder.This very large international study examined over 47,000 subjects followed between 2001 and 2011.Baseline psychiatric assessment was completed using the Composite International Diagnostic Interview. Physical illness was assessed using a self-report of physician's diagnosis.The manuscript is not free but I was able to obtain a professional courtesy copy of........ Read more »
Scott KM, Lim C, Al-Hamzawi A, Alonso J, Bruffaerts R, Caldas-de-Almeida JM, Florescu S, de Girolamo G, Hu C, de Jonge P.... (2015) Association of Mental Disorders With Subsequent Chronic Physical Conditions: World Mental Health Surveys From 17 Countries. JAMA psychiatry, 1-9. PMID: 26719969
- January 4, 2016
- 01:59 PM
- 389 views
Meta-Research: Getting the Most Out of Research
by Roli Roberts in PLOS Biologue
Scientific research, often portrayed as the acme of human rigorous thought, is actually an activity that’s grown rather organically over the centuries from Aristotle, via Bacon, to an endeavour that now involves millions of people... Read more »
Cumming, T., Churilov, L., & Sena, E. (2015) The Missing Medians: Exclusion of Ordinal Data from Meta-Analyses. PLOS ONE, 10(12). DOI: 10.1371/journal.pone.0145580
- December 29, 2015
- 04:30 PM
- 577 views
This Month in Blastocystis Research (DEC 2015)
by Christen Rune Stensvold in Blastocystis Parasite Blog
Practically all Blastocystis research has focussed on identifying a role for the parasite in disease. Meanwhile, no one has really tried to looked into what Blastocystis may tell us about human health. Together with partner labs, our lab has produced data suggesting that Blastocystis carriage is extremely common, and probably also extremely long lasting. We have also shown that the parasite is associated with certain gut microbial communities and that it is more common in healthy individuals tha........ Read more »
Andersen LO, & Stensvold CR. (2015) Blastocystis in Health and Disease-Are We Moving from a Clinical to a Public Health Perspective?. Journal of clinical microbiology. PMID: 26677249
- December 23, 2015
- 10:27 AM
- 344 views
Paid Sick Leave May Help Cancer Patient Retain Jobs
by Marie Benz in MedicalResearch.com
MedicalResearch.com Interview with: Christine Veenstra MD Clinical Lecturer, Internal Medicine Medical Oncology University of Michigan Ann Arbor, MI 48109-5343 MedicalResearch: What is the background for this study? What are the main findings? Dr. Veenstra: Patients with cancer face many costs … Continue reading →
The post Paid Sick Leave May Help Cancer Patient Retain Jobs appeared first on MedicalResearch.com.
... Read more »
Christine Veenstra MD. (2015) Paid Sick Leave May Help Cancer Patient Retain Jobs. MedicalResearch.com. info:/
- December 11, 2015
- 12:41 AM
- 884 views
The Apocalypse is HERE: Transmissible Resistance to Last Resort Antibiotic (Colistin)
by Pranab Chatterjee in Scepticemia
Polymyxins are a group of bacterial origin cyclic polypeptides with antibacterial properties. It was isolated by a Japanese researcher in 1949 from a jar of fermenting bacteria. Colistin, also known as Polymyxin E, which is produced by the bacteria Paenibacillus polymyxa var. colistinus, is a polypeptide antibiotic, which is effective against almost all gram-negative bacilli. Owing to its nephrotoxocity and…... Read more »
Liu, Y., Wang, Y., Walsh, T., Yi, L., Zhang, R., Spencer, J., Doi, Y., Tian, G., Dong, B., Huang, X.... (2015) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. The Lancet Infectious Diseases. DOI: 10.1016/S1473-3099(15)00424-7
- December 8, 2015
- 01:50 PM
- 403 views
Why is progress so slow in resuscitation research?
by Rogue Medic in Rogue Medic
Why is progress so slow in resuscitation research? A lot of money and time went in to finding out which type of blood-letting ventilation works best – ignoring the absence of valid evidence that ventilation is better than no ventilation. Why not gamble with our patients?
In response to The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR,[1],[2] Kenny commented that –
there are many things in your blog that are not correct.[1]... Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
- December 3, 2015
- 09:21 AM
- 386 views
What’s the Answer? (Dare we edit the human race?) #GeneEditSummit
This week’s question is a biggie. And there’s no answer yet. But that is the topic of the National Academies big event this week, International Summit on Human Gene Editing. I have been glued to this for the whole time and didn’t spend much time looking for questions this week. And I’ll be watching the final […]... Read more »
Reardon, S. (2015) Human-genome editing summit to sample global attitudes. Nature. DOI: 10.1038/nature.2015.18879
- December 2, 2015
- 11:37 AM
- 287 views
Treatment Guidelines for Problem Gambling
by William Yates, M.D. in Brain Posts
Basal ganglia may be involving in gambling disorderProblem gambling effects a number of individuals who engage in gambling behavior.Gambling behavior that meets criteria as a Gambling Disorder according to the criteria of DSM-5 includes four or more of the following over a consecutive 12 month period of time:Increased quantity of money gambled to achieve excitementRestlessness/irritability when attempting to cut down gambling behaviorRepeated unsuccessful attempts to cut down or stop gamblingPre........ Read more »
Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000
- November 29, 2015
- 01:41 PM
- 478 views
It is possible to develop successful HIV vaccine
by B V Waghmare in HIV virus and antiretroviral drugs and antiAIDS vaccine research and developmets
Antibodies developed in HIV infected individuals do not protect them against further proliferation of HIV, but protect proliferation of HIV in animals.
That means it is possible to develop a vaccine which will completely protect human from HIV infection.... Read more »
B V Waghmare. (2015) HIV Vaccine heading toward success. Combination of HIV neutralizing antibodies and Nanoparticle protien eOD-GT8 60mer are good hope for getting a effective anti HIV vaccine. http://bvwaghmare.blogspot.com. info:/
- November 25, 2015
- 10:15 AM
- 571 views
The Fatal Flaw in Trial of Continuous or Interrupted Chest Compressions during CPR
by Rogue Medic in Rogue Medic
This is not a study that has a valid control group to determine if there is any benefit from ventilation. There is no group that does not receive ventilations, so it is like a study of one type of blood-letting vs. another type of blood-letting with the researchers taking for granted that blood-letting does improve outcomes. That is not a problem if blood-letting actually improves outcomes.
Should we take it for granted that blood-letting improves outcomes and that the only hypothesis worth s........ Read more »
Nichol, G., Leroux, B., Wang, H., Callaway, C., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L., Aufderheide, T., Cheskes, S.... (2015) Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine, 2147483647. DOI: 10.1056/NEJMoa1509139
Alldredge BK,, Gelb AM,, Isaacs SM,, Corry MD,, Allen F,, Ulrich S,, Gottwald MD,, O’Neil N,, Neuhaus JM,, Segal MR,.... (2001) A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(25), 1860-1860. DOI: 10.1056/NEJM200112203452521
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