by William Yates, M.D. in Brain Posts
The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »
Cerqueira CT, Sato JR, de Almeida JR, Amaro E Jr, Leite CC, Gorenstein C, Gentil V, & Busatto GF. (2014) Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions. Translational psychiatry. PMID: 24984192
by William Yates, M.D. in Brain Posts
Some individuals appear vulnerable to paranoia induced by exposure to tetrahydrocannabinol (THC) in cannabis.The mechanism for this effect is poorly understood.Daniel Freeman from University of Oxford along with colleagues in England and Switzerland recently conducted an interventional research study on this issue.In this study, 121 subjects were recruited to receive injections of THC in a laboratory setting.These subjects were required to have taken cannabis at least once before participation i........ Read more »
Freeman D, Dunn G, Murray RM, Evans N, Lister R, Antley A, Slater M, Godlewska B, Cornish R, Williams J.... (2014) How Cannabis Causes Paranoia: Using the Intravenous Administration of ∆9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia. Schizophrenia bulletin. PMID: 25031222
by Andrea in Science of Eating Disorders
It can be somewhat controversial to suggest that untreated recovery from eating disorders is possible. Certainly, people have varied opinions about whether someone can enact the difficult behavioral and attitudinal changes necessary to recover without the help of (at the very least) a therapist and a dietitian. Nonetheless, we still hear stories about individuals who consider themselves recovered without having sought out external sources of professional support.
When I think about untreat........ Read more »
Vandereycken W. (2012) Self-change in eating disorders: is "spontaneous recovery" possible?. Eating disorders, 20(2), 87-98. PMID: 22364341
Woods S. (2004) Untreated recovery from eating disorders. Adolescence, 39(154), 361-71. PMID: 15563044
by Andrea in Science of Eating Disorders
Another issue in defining and understanding recovery is that patients and clinicians may have different opinions about what recovery looks like and how to get there. Certainly, there is a body of literature from the critical feminist tradition in particular that explores how at times, patients can “follow the rules” of treatment systems to achieve a semblance of “recovery,” from a weight restoration and nutrition stabilization perspective, but feels nothing like a full and happy li........ Read more »
Noordenbos, G., & Seubring, A. (2006) Criteria for Recovery from Eating Disorders According to Patients and Therapists. Eating Disorders, 14(1), 41-54. DOI: 10.1080/10640260500296756
by William Yates, M.D. in Brain Posts
One method to advance understanding of a disorder is to use statistical modeling for sub-type or class analysis.Lia Nower and colleagues recently published the results of such an analysis from the large general population data-set known as the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).In this sample, 851 adults 18 years and older were identified with disordered gambling.This group then underwent a type of latent class statistical analysis known as the Pathways........ Read more »
Nower L, Martins SS, Lin KH, & Blanco C. (2013) Subtypes of disordered gamblers: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Addiction (Abingdon, England), 108(4), 789-98. PMID: 23072599
by William Yates, M.D. in Brain Posts
Behavioral disorders like pathological gambling (PG) rarely occur alone as a single uncomplicated disorder.In a previous post, I noted the overlap of PG with personality disorder, anxiety disorder, depression, bipolar disorder and substance abuse.A recent study from Germany adds to our knowledge of the general diagnostic profile in the PG population.Erbas and Buchner reviewed German national data sources and other German studies to come up with a series of findings:Twelve month prevalence rates ........ Read more »
Erbas B, & Buchner UG. (2012) Pathological gambling: prevalence, diagnosis, comorbidity, and intervention in Germany. Deutsches Arzteblatt international, 109(10), 173-9. PMID: 22470406
by DJMac in Recovery Review
A few years back in a city far, far away, I asked a consultant addiction psychiatrist why he did not refer any of his patients to NA. “There’s not a shred of evidence that it works,” he said. Even then he was misinformed, but I’ve thought many times since then about how his patients were [...]
The post Narcotics Anonymous for military veterans appeared first on Recovery Review.
... Read more »
Galanter M, Dermatis H, & Sampson C. (2014) Narcotics anonymous: a comparison of military veterans and non-veterans. Journal of addictive diseases. PMID: 25115224
by Andrea in Science of Eating Disorders
Today I have the distinct pleasure of writing about one of my favourite articles about eating disorder recovery by Malson et al. (2011) exploring how inpatients talk about eating disorder recovery. I have personally found this article to be very helpful in understanding some of the difficulties of understanding and achieving recovery in our social context.
As Malson and colleagues explain (and as we’ve established), eating disorder recovery is elusive. Often, poor prognosis is described ........ Read more »
Malson H, Bailey L, Clarke S, Treasure J, Anderson G, & Kohn M. (2011) Un/imaginable future selves: a discourse analysis of in-patients' talk about recovery from an 'eating disorder'. European eating disorders review : the journal of the Eating Disorders Association, 19(1), 25-36. PMID: 21182163
by nooffensebut in The Unsilenced Science
Geneticists are not the leading experts on behavioral genetics, and they and other critics have made numerous errors and misjudgments about Nicholas Wade’s book A Troublesome Inheritance, as well as MAOA or warrior gene research.... Read more »
Beaver KM, Barnes JC, & Boutwell BB. (2013) The 2-Repeat Allele of the MAOA Gene Confers an Increased Risk for Shooting and Stabbing Behaviors. The Psychiatric quarterly. PMID: 24326626
Beaver, K., Wright, J., Boutwell, B., Barnes, J., DeLisi, M., & Vaughn, M. (2013) Exploring the association between the 2-repeat allele of the MAOA gene promoter polymorphism and psychopathic personality traits, arrests, incarceration, and lifetime antisocial behavior. Personality and Individual Differences, 54(2), 164-168. DOI: 10.1016/j.paid.2012.08.014
Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S.... (2010) A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature, 468(7327), 1061-6. PMID: 21179162
Brunner HG, Nelen MR, van Zandvoort P, Abeling NG, van Gennip AH, Wolters EC, Kuiper MA, Ropers HH, & van Oost BA. (1993) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. American journal of human genetics, 52(6), 1032-9. PMID: 8503438
Byrd AL, & Manuck SB. (2013) MAOA, Childhood Maltreatment, and Antisocial Behavior: Meta-analysis of a Gene-Environment Interaction. Biological psychiatry. PMID: 23786983
Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, & Shih JC. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science (New York, N.Y.), 268(5218), 1763-6. PMID: 7792602
Donnai D, Mountford RC, & Read AP. (1988) Norrie disease resulting from a gene deletion: clinical features and DNA studies. Journal of medical genetics, 25(2), 73-8. PMID: 3162283
Ficks CA, & Waldman ID. (2014) Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR. Behavior genetics. PMID: 24902785
Gibbons, A. (2004) AMERICAN ASSOCIATION OF PHYSICAL ANTHROPOLOGISTS MEETING: Tracking the Evolutionary History of a "Warrior" Gene. Science, 304(5672), 818-818. DOI: 10.1126/science.304.5672.818a
Guo, G., Roettger, M., & Cai, T. (2008) The Integration of Genetic Propensities into Social-Control Models of Delinquency and Violence among Male Youths. American Sociological Review, 73(4), 543-568. DOI: 10.1177/000312240807300402
Guo, G., Ou, X., Roettger, M., & Shih, J. (2008) The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. European Journal of Human Genetics, 16(5), 626-634. DOI: 10.1038/sj.ejhg.5201999
Philibert RA, Wernett P, Plume J, Packer H, Brody GH, & Beach SR. (2011) Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder. Biological psychology, 87(3), 366-71. PMID: 21554924
Tsuchimine S, Taniguchi T, Sugawara N, Kaneda A, & Yasui-Furukori N. (2013) No Association between a polymorphism in the serotonin receptor 2B (HTR2B) gene and personality traits in healthy Japanese subjects. Neuropsychobiology, 68(1), 59-62. PMID: 23774082
Tuinier S, Verhoeven WMA, Scherders MJWT, Fekkes D, & Pepplinkhuizen L. (1995) Neuropsychiatric and biological characteristics of X-linked MAO-A deficiency syndrome. A single case intervention study. New Trends in Experimental and Clinical Psychiatry, 99-107. info:/
Zhu B, Chen C, Moyzis R, Dong Q, Chen C, He Q, Li J, Lei X, & Lin C. (2012) Association between the HTR2B gene and the personality trait of fun seeking. Personality and Individual Differences, 53(8), 1029-1033. DOI: 10.1016/j.paid.2012.07.026
by Liz in Science of Eating Disorders
As a follow up to Shirley’s post on eating hyper-palatable foods during eating disorder treatment , I asked Liz-SEDs’ resident expert on animal behaviour, particularly in relation to binge eating and drug addiction-to look at some of the studies that Julie O’Toole mentioned as evidence for Kartini Clinic’s guidelines of avoiding hyper-palatable foods for the first year of eating disorder recovery. If you missed Dr. O’Toole’s post, please........ Read more »
Hagan, M.M., Wauford, P.K., Chandler, P.C., Jarrett, L.A., Rybak, R.J., & Blackburn, K. (2002) A new animal model of binge eating: key synergistic role of past caloric restriction and stress. Physiology , 77(1), 45-54. PMID: 12213501
by William Yates, M.D. in Brain Posts
Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders". In their summa........ Read more »
Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000
by Shirley in Science of Eating Disorders
Should eating disorder patients be introduced to “junk food” or “hyper-palatable” foods during treatment? A few days ago, I stumbled across a blog post where Dr. Julie O’Toole, Founder and Director of the Kartini Clinic for Disordered Eating, argues against introducing “junk food” during ED treatment. The crux of the argument is that “hyperpalatable foods”—e.g., chips and Cheetos—are not real food and should never be forced or encouraged for anyone, regard........ Read more »
Spring, V.L., & Bulik, C.M. (2014) Implicit and explicit affect toward food and weight stimuli in anorexia nervosa. Eating Behaviors, 15(1), 91-4. PMID: 24411758
Steinglass, J.E., Sysko, R., Glasofer, D., Albano, A.M., Simpson, H.B., & Walsh, B.T. (2011) Rationale for the application of exposure and response prevention to the treatment of anorexia nervosa. The International Journal of Eating Disorders, 44(2), 134-41. PMID: 20127936
by Mark E. Lasbury in The 'Scope
Robin William’s suicide was a tragic, but all too familiar happening amongst humorists of this period. New research is showing that comedians, performers in the arts, and even people with better senses of humor are prone to more health problems as adults. Depression , cardiovascular, pulmonary and stress related problem are not uncommon in comedians, and even children and adults that have better sense of humor are susceptible to obesity and cardiovascular disease.
The irony is that t........ Read more »
C.R. Epstein, R.J. Epstein. (2013) Death in The New York Times: the price of fame is a faster flame . QJM: monthly journal of the Association of Physicians, 106(6), 517-521. info:/
Greengross G. (2013) Humor and aging - a mini-review. Gerontology, 59(5), 448-53. PMID: 23689078
Ferner RE, & Aronson JK. (2013) Laughter and MIRTH (Methodical Investigation of Risibility, Therapeutic and Harmful): narrative synthesis. BMJ (Clinical research ed.). PMID: 24336308
Bennett MP, & Lengacher C. (2009) Humor and Laughter May Influence Health IV. Humor and Immune Function. Evidence-based complementary and alternative medicine : eCAM, 6(2), 159-64. PMID: 18955287
by William Yates, M.D. in Brain Posts
Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »
Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269
by DJMac in Recovery Review
Evidence has accumulated over the last couple of decades of the association between attendance at Alcoholics Anonymous and improved drinking outcomes, including abstinence. AA is sometimes seen as an organisation that is better suited to older drinkers seeking sobriety than to folk under thirty, though there are in fact young people’s meetings in various large [...]
The post Does AA work for young people? appeared first on Recovery Review.
... Read more »
Hoeppner, B., Hoeppner, S., & Kelly, J. (2014) Do young people benefit from AA as much, and in the same ways, as adult aged 30 ? A moderated multiple mediation analysis. Drug and Alcohol Dependence. DOI: 10.1016/j.drugalcdep.2014.07.023
by Andrea in Science of Eating Disorders
What does eating disorder recovery really look like? When you say the word “recovery,” differences of opinion loom large. The lack of definitional clarity around the concept of recovery came up many times at ICED, and continues to surface in discussions among researchers, clinicians, and individuals with eating disorders themselves. We’ve looked at recovery on the blog before (for example, Gina looked at how patients define recovery here; Tetyana surveyed readers about th........ Read more »
Dawson L, Rhodes P, & Touyz S. (2014) The recovery model and anorexia nervosa. The Australian and New Zealand journal of psychiatry. PMID: 24927735
by nooffensebut in The Unsilenced Science
Two respected authors, Alondra Oubré and Massimo Pigliucci, are implicated in the academic fraud of taking false information from Wikipedia and falsely attributing it to a research database in order to fulminate against the conclusions of Nicholas Wade’s book, A Troublesome Inheritance, and the science of the warrior gene, monoamine oxidase A.... Read more »
Alia-Klein N, Goldstein RZ, Tomasi D, Woicik PA, Moeller SJ, Williams B, Craig IW, Telang F, Biegon A, Wang GJ.... (2009) Neural mechanisms of anger regulation as a function of genetic risk for violence. Emotion (Washington, D.C.), 9(3), 385-96. PMID: 19485616
Balciuniene J, Syvänen AC, McLeod HL, Pettersson U, & Jazin EE. (2001) The geographic distribution of monoamine oxidase haplotypes supports a bottleneck during the dispersion of modern humans from Africa. Journal of molecular evolution, 52(2), 157-63. PMID: 11231895
Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, & Meyer-Lindenberg A. (2008) Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular psychiatry, 13(3), 313-24. PMID: 17519928
Cerasa A, Cherubini A, Quattrone A, Gioia MC, Magariello A, Muglia M, Manna I, Assogna F, Caltagirone C, & Spalletta G. (2010) Morphological correlates of MAO A VNTR polymorphism: new evidence from cortical thickness measurement. Behavioural brain research, 211(1), 118-24. PMID: 20303364
Ficks CA, & Waldman ID. (2014) Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR. Behavior genetics. PMID: 24902785
Fergusson DM, Boden JM, Horwood LJ, Miller A, & Kennedy MA. (2012) Moderating role of the MAOA genotype in antisocial behaviour. The British journal of psychiatry : the journal of mental science, 200(2), 116-23. PMID: 22297589
Gilad Y, Rosenberg S, Przeworski M, Lancet D, & Skorecki K. (2002) Evidence for positive selection and population structure at the human MAO-A gene. Proceedings of the National Academy of Sciences of the United States of America, 99(2), 862-7. PMID: 11805333
Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, & Mann JJ. (2004) An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(8), 1498-505. PMID: 15150530
Koen L, Kinnear C, Corfield V, Emsley R, Jordaan E, Keyter N, Moolman-Smook J, Stein D, & Niehaus D. (2004) Violence in male patients with schizophrenia: risk markers in a South African population. Australian and New Zealand Journal of Psychiatry, 38(4), 254-259. DOI: 10.1111/j.1440-1614.2004.01338.x
Kunugi H, Ishida S, Kato T, Tatsumi M, Sakai T, Hattori M, Hirose T, & Nanko S. (1999) A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Molecular psychiatry, 4(4), 393-5. PMID: 10483059
Lei H, Zhang X, Di X, Rao H, Ming Q, Zhang J, Guo X, Jiang Y, Gao Y, Yi J.... (2014) A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed research international, 243280. PMID: 24971323
Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, & Maeda K. (2002) No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides. American journal of medical genetics, 114(3), 340-2. PMID: 11920860
Philibert RA, Gunter TD, Beach SR, Brody GH, & Madan A. (2008) MAOA methylation is associated with nicotine and alcohol dependence in women. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B(5), 565-70. PMID: 18454435
Pinsonneault JK, Papp AC, & Sadée W. (2006) Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors. Human molecular genetics, 15(17), 2636-49. PMID: 16893905
Rosenberg S, Templeton AR, Feigin PD, Lancet D, Beckmann JS, Selig S, Hamer DH, & Skorecki K. (2006) The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males. Human genetics, 120(4), 447-59. PMID: 16896926
Sabol S, Hu S, & Hamer D. (2014) A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103(3), 273-279. DOI: 10.1007/s004390050816
Widom CS, & Brzustowicz LM. (2006) MAOA and the "cycle of violence:" childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological psychiatry, 60(7), 684-9. PMID: 16814261
Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M.... (2003) Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(3), 533-41. PMID: 12629534
Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, & Mill J. (2010) A longitudinal study of epigenetic variation in twins. Epigenetics : official journal of the DNA Methylation Society, 5(6), 516-26. PMID: 20505345
Young SE, Smolen A, Hewitt JK, Haberstick BC, Stallings MC, Corley RP, & Crowley TJ. (2006) Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patients. The American journal of psychiatry, 163(6), 1019-25. PMID: 16741202
Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, & Yang CW. (2005) Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30(9), 1719-23. PMID: 15956990
by Tetyana in Science of Eating Disorders
Although the words “anorexia nervosa” typically conjure up images of emaciated bodies, eating disorders characterized by dietary restriction or weight loss can — and do — occur at any weight. However, precisely because anorexia nervosa is associated with underweight, doctors are less likely to identify eating disorders among individuals who are in the so-called “normal” or above normal weight range, even if they have........ Read more »
Lebow, J., Sim, L., & Kransdorf, L. (2014) Prevalence of a History of Overweight and Obesity in Adolescents With Restrictive Eating Disorders. Journal of Adolescent Health. DOI: 10.1016/j.jadohealth.2014.06.005
by The Neurocritic in The Neurocritic
The creation of the category “Twitter Psychosis" tells us more about the culture of contemporary psychiatry than it does about the purported dangers of social media overuse. Can Twitter really “cause” psychotic symptoms in predisposed individuals? Or is Twitter merely the latest technical innovation that influences “the form, origin and content of delusional beliefs” (Bell et al., 2005)? Twitter as the new telephone tower, radio waves, microchip implant or personal TV show, if you wil........ Read more »
Kalbitzer J, Mell T, Bermpohl F, Rapp MA, & Heinz A. (2014) Twitter Psychosis: A Rare Variation or a Distinct Syndrome?. The Journal of nervous and mental disease, 202(8), 623. PMID: 25075647
by William Yates, M.D. in Brain Posts
Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »
Fazel S, Wolf A, Pillas D, Lichtenstein P, & Långström N. (2014) Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: a 41-year Swedish population study. JAMA psychiatry, 71(3), 326-33. PMID: 24430827
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