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  • September 17, 2014
  • 11:28 AM
  • 680 views

Antidepressants Modulate Memory in the Healthy Brain

by William Yates, M.D. in Brain Posts

The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the antidepr........ Read more »

  • September 16, 2014
  • 11:01 AM
  • 705 views

Cannabis-induced Paranoia: Cognitive Mechanisms

by William Yates, M.D. in Brain Posts

Some individuals appear vulnerable to paranoia induced by exposure to tetrahydrocannabinol (THC) in cannabis.The mechanism for this effect is poorly understood.Daniel Freeman from University of Oxford along with colleagues in England and Switzerland recently conducted an interventional research study on this issue.In this study, 121 subjects were recruited to receive injections of THC in a laboratory setting.These subjects were required to have taken cannabis at least once before participation i........ Read more »

  • September 6, 2014
  • 02:11 PM
  • 795 views

Unpacking Recovery Part 5: Clinical Recovery without a Clinic?

by Andrea in Science of Eating Disorders


It can be somewhat controversial to suggest that untreated recovery from eating disorders is possible. Certainly, people have varied opinions about whether someone can enact the difficult behavioral and attitudinal changes necessary to recover without the help of (at the very least) a therapist and a dietitian. Nonetheless, we still hear stories about individuals who consider themselves recovered without having sought out external sources of professional support.
When I think about untreat........ Read more »

  • September 1, 2014
  • 11:46 PM
  • 790 views

Unpacking Recovery Part 4: Are We All on the Same Page?

by Andrea in Science of Eating Disorders


Another issue in defining and understanding recovery is that patients and clinicians may have different opinions about what recovery looks like and how to get there. Certainly, there is a body of literature from the critical feminist tradition in particular that explores how at times, patients can “follow the rules” of treatment systems to achieve a semblance of “recovery,” from a weight restoration and nutrition stabilization perspective, but feels nothing like a full and happy li........ Read more »

Noordenbos, G., & Seubring, A. (2006) Criteria for Recovery from Eating Disorders According to Patients and Therapists. Eating Disorders, 14(1), 41-54. DOI: 10.1080/10640260500296756  

  • August 28, 2014
  • 11:40 AM
  • 858 views

Gambler Sub-types: Three Distinct Profiles

by William Yates, M.D. in Brain Posts

One method to advance understanding of a disorder is to use statistical modeling for sub-type or class analysis.Lia Nower and colleagues recently published the results of such an analysis from the large general population data-set known as the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).In this sample, 851 adults 18 years and older were identified with disordered gambling.This group then underwent a type of latent class statistical analysis known as the Pathways........ Read more »

  • August 27, 2014
  • 10:58 AM
  • 779 views

Diagnostic Profile in Pathological Gamblers

by William Yates, M.D. in Brain Posts

Behavioral disorders like pathological gambling (PG) rarely occur alone as a single uncomplicated disorder.In a previous post, I noted the overlap of PG with personality disorder, anxiety disorder, depression, bipolar disorder and substance abuse.A recent study from Germany adds to our knowledge of the general diagnostic profile in the PG population.Erbas and Buchner reviewed German national data sources and other German studies to come up with a series of findings:Twelve month prevalence rates ........ Read more »

  • August 26, 2014
  • 07:01 PM
  • 795 views

Narcotics Anonymous for military veterans

by DJMac in Recovery Review

A few years back in a city far, far away, I asked a consultant addiction psychiatrist why he did not refer any of his patients to NA. “There’s not a shred of evidence that it works,” he said. Even then he was misinformed, but I’ve thought many times since then about how his patients were [...]
The post Narcotics Anonymous for military veterans appeared first on Recovery Review.
... Read more »

  • August 25, 2014
  • 03:38 PM
  • 600 views

Unpacking Recovery Part 3: Can Patients Imagine Recovery?

by Andrea in Science of Eating Disorders


Today I have the distinct pleasure of writing about one of my favourite articles about eating disorder recovery by Malson et al. (2011) exploring how inpatients talk about eating disorder recovery. I have personally found this article to be very helpful in understanding some of the difficulties of understanding and achieving recovery in our social context.
As Malson and colleagues explain (and as we’ve established), eating disorder recovery is elusive. Often, poor prognosis is described ........ Read more »

Malson H, Bailey L, Clarke S, Treasure J, Anderson G, & Kohn M. (2011) Un/imaginable future selves: a discourse analysis of in-patients' talk about recovery from an 'eating disorder'. European eating disorders review : the journal of the Eating Disorders Association, 19(1), 25-36. PMID: 21182163  

  • August 24, 2014
  • 03:06 PM
  • 1,046 views

Correcting the Critics of Nicholas Wade & MAOA

by nooffensebut in The Unsilenced Science

Geneticists are not the leading experts on behavioral genetics, and they and other critics have made numerous errors and misjudgments about Nicholas Wade’s book A Troublesome Inheritance, as well as MAOA or warrior gene research.... Read more »

Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S.... (2010) A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature, 468(7327), 1061-6. PMID: 21179162  

Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, & Shih JC. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science (New York, N.Y.), 268(5218), 1763-6. PMID: 7792602  

Gibbons, A. (2004) AMERICAN ASSOCIATION OF PHYSICAL ANTHROPOLOGISTS MEETING: Tracking the Evolutionary History of a "Warrior" Gene. Science, 304(5672), 818-818. DOI: 10.1126/science.304.5672.818a  

Guo, G., Roettger, M., & Cai, T. (2008) The Integration of Genetic Propensities into Social-Control Models of Delinquency and Violence among Male Youths. American Sociological Review, 73(4), 543-568. DOI: 10.1177/000312240807300402  

Tuinier S, Verhoeven WMA, Scherders MJWT, Fekkes D, & Pepplinkhuizen L. (1995) Neuropsychiatric and biological characteristics of X-linked MAO-A deficiency syndrome. A single case intervention study. New Trends in Experimental and Clinical Psychiatry, 99-107. info:/

Zhu B, Chen C, Moyzis R, Dong Q, Chen C, He Q, Li J, Lei X, & Lin C. (2012) Association between the HTR2B gene and the personality trait of fun seeking. Personality and Individual Differences, 53(8), 1029-1033. DOI: 10.1016/j.paid.2012.07.026  

  • August 22, 2014
  • 06:51 PM
  • 708 views

Using Animal Research to Justify Eating Disorder Treatment Practices: Are We Going Too Far? (On Eating Junk Food in Treatment – Part II)

by Liz in Science of Eating Disorders


As a follow up to Shirley’s post on eating hyper-palatable foods during eating disorder treatment , I asked Liz-SEDs’ resident expert on animal behaviour, particularly in relation to binge eating and drug addiction-to look at some of the studies that Julie O’Toole mentioned as evidence for Kartini Clinic’s guidelines of avoiding hyper-palatable foods for the first year of eating disorder recovery. If you missed Dr. O’Toole’s post, please........ Read more »

Hagan, M.M., Wauford, P.K., Chandler, P.C., Jarrett, L.A., Rybak, R.J., & Blackburn, K. (2002) A new animal model of binge eating: key synergistic role of past caloric restriction and stress. Physiology , 77(1), 45-54. PMID: 12213501  

  • August 18, 2014
  • 10:16 AM
  • 751 views

Guidelines for Treatment of Problem Gambling

by William Yates, M.D. in Brain Posts

Despite the prevalence and impact of problem gambling, few summaries or guidelines address treatment.Searching the guideline.gov website shows no recent additions to the guideline literature.A guideline was published by the Singapore Ministry of Health in 2011. This guideline is still relevant and highlights some of the key elements of a problem gambling treatment program.I will summarize some of these key elements from this source titled: "Management of gambling disorders".  In their summa........ Read more »

Lee KM, Chan HN, Cheah B, Gentica GF, Guo S, Lim HK, Lim YC, Noorul F, Tan HS, Teo P.... (2011) Ministry of Health clinical practice guidelines: management of gambling disorders. Singapore medical journal, 52(6), 456. PMID: 21732000  

  • August 15, 2014
  • 03:20 PM
  • 1,884 views

In Defense of Eating Junk Food in Eating Disorder Treatment

by Shirley in Science of Eating Disorders


Should eating disorder patients be introduced to “junk food” or “hyper-palatable” foods during treatment? A few days ago, I stumbled across a blog post where Dr. Julie O’Toole, Founder and Director of the Kartini Clinic for Disordered Eating, argues against introducing “junk food” during ED treatment. The crux of the argument is that “hyperpalatable foods”—e.g., chips and Cheetos—are not real food and should never be forced or encouraged for anyone, regard........ Read more »

  • August 14, 2014
  • 02:00 PM
  • 1,514 views

Dying To Make Us Laugh

by Mark E. Lasbury in The 'Scope

Robin William’s suicide was a tragic, but all too familiar happening amongst humorists of this period. New research is showing that comedians, performers in the arts, and even people with better senses of humor are prone to more health problems as adults. Depression , cardiovascular, pulmonary and stress related problem are not uncommon in comedians, and even children and adults that have better sense of humor are susceptible to obesity and cardiovascular disease.

The irony is that t........ Read more »

C.R. Epstein, R.J. Epstein. (2013) Death in The New York Times: the price of fame is a faster flame . QJM: monthly journal of the Association of Physicians, 106(6), 517-521. info:/

Greengross G. (2013) Humor and aging - a mini-review. Gerontology, 59(5), 448-53. PMID: 23689078  

Bennett MP, & Lengacher C. (2009) Humor and Laughter May Influence Health IV. Humor and Immune Function. Evidence-based complementary and alternative medicine : eCAM, 6(2), 159-64. PMID: 18955287  

  • August 11, 2014
  • 11:42 AM
  • 661 views

Clinical Drug Trials for Pathological Gambling

by William Yates, M.D. in Brain Posts

Several drug classes hold promise for reduction in pathological gambling behavior.However, there are very few published randomized and controlled clinical drug trials in gambling subjects.Searching clinical trials and gambling on PubMed yields only one small open-label proof of concept trial for the drug tolcapone within the last year.This study found evidence that this COMT inhibitor drug reduced gambling symptoms and was accompanied by fronto-parietal activation on fMRI imaging.However, on sea........ Read more »

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, & Kim SW. (2013) A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1587-96. PMID: 23953269  

  • August 6, 2014
  • 02:27 AM
  • 942 views

Does AA work for young people?

by DJMac in Recovery Review

Evidence has accumulated over the last couple of decades of the association between attendance at Alcoholics Anonymous and improved drinking outcomes, including abstinence. AA is sometimes seen as an organisation that is better suited to older drinkers seeking sobriety than to folk under thirty, though there are in fact young people’s meetings in various large [...]
The post Does AA work for young people? appeared first on Recovery Review.
... Read more »

  • August 4, 2014
  • 10:43 AM
  • 1,199 views

Unpacking Eating Disorder Recovery Part 1: The Recovery Model

by Andrea in Science of Eating Disorders


What does eating disorder recovery really look like? When you say the word “recovery,” differences of opinion loom large. The lack of definitional clarity around the concept of recovery came up many times at ICED, and continues to surface in discussions among researchers, clinicians, and individuals with eating disorders themselves. We’ve looked at recovery on the blog before (for example, Gina looked at how patients define recovery here; Tetyana surveyed readers about th........ Read more »

Dawson L, Rhodes P, & Touyz S. (2014) The recovery model and anorexia nervosa. The Australian and New Zealand journal of psychiatry. PMID: 24927735  

  • August 3, 2014
  • 04:11 PM
  • 1,270 views

The Alondra Oubré Academic Fraud Exposed

by nooffensebut in The Unsilenced Science

Two respected authors, Alondra Oubré and Massimo Pigliucci, are implicated in the academic fraud of taking false information from Wikipedia and falsely attributing it to a research database in order to fulminate against the conclusions of Nicholas Wade’s book, A Troublesome Inheritance, and the science of the warrior gene, monoamine oxidase A.... Read more »

Alia-Klein N, Goldstein RZ, Tomasi D, Woicik PA, Moeller SJ, Williams B, Craig IW, Telang F, Biegon A, Wang GJ.... (2009) Neural mechanisms of anger regulation as a function of genetic risk for violence. Emotion (Washington, D.C.), 9(3), 385-96. PMID: 19485616  

Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, & Meyer-Lindenberg A. (2008) Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular psychiatry, 13(3), 313-24. PMID: 17519928  

Cerasa A, Cherubini A, Quattrone A, Gioia MC, Magariello A, Muglia M, Manna I, Assogna F, Caltagirone C, & Spalletta G. (2010) Morphological correlates of MAO A VNTR polymorphism: new evidence from cortical thickness measurement. Behavioural brain research, 211(1), 118-24. PMID: 20303364  

Fergusson DM, Boden JM, Horwood LJ, Miller A, & Kennedy MA. (2012) Moderating role of the MAOA genotype in antisocial behaviour. The British journal of psychiatry : the journal of mental science, 200(2), 116-23. PMID: 22297589  

Gilad Y, Rosenberg S, Przeworski M, Lancet D, & Skorecki K. (2002) Evidence for positive selection and population structure at the human MAO-A gene. Proceedings of the National Academy of Sciences of the United States of America, 99(2), 862-7. PMID: 11805333  

Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, & Mann JJ. (2004) An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(8), 1498-505. PMID: 15150530  

Koen L, Kinnear C, Corfield V, Emsley R, Jordaan E, Keyter N, Moolman-Smook J, Stein D, & Niehaus D. (2004) Violence in male patients with schizophrenia: risk markers in a South African population. Australian and New Zealand Journal of Psychiatry, 38(4), 254-259. DOI: 10.1111/j.1440-1614.2004.01338.x  

Kunugi H, Ishida S, Kato T, Tatsumi M, Sakai T, Hattori M, Hirose T, & Nanko S. (1999) A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Molecular psychiatry, 4(4), 393-5. PMID: 10483059  

Lei H, Zhang X, Di X, Rao H, Ming Q, Zhang J, Guo X, Jiang Y, Gao Y, Yi J.... (2014) A Functional Polymorphism of the MAOA Gene Modulates Spontaneous Brain Activity in Pons. BioMed research international, 243280. PMID: 24971323  

Philibert RA, Gunter TD, Beach SR, Brody GH, & Madan A. (2008) MAOA methylation is associated with nicotine and alcohol dependence in women. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B(5), 565-70. PMID: 18454435  

Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M.... (2003) Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(3), 533-41. PMID: 12629534  

Wong CC, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, & Mill J. (2010) A longitudinal study of epigenetic variation in twins. Epigenetics : official journal of the DNA Methylation Society, 5(6), 516-26. PMID: 20505345  

Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, & Yang CW. (2005) Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30(9), 1719-23. PMID: 15956990  

  • July 31, 2014
  • 07:18 PM
  • 1,303 views

Serious Restrictive Eating Disorders Occur at Any Weight

by Tetyana in Science of Eating Disorders


Although the words “anorexia nervosa” typically conjure up images of emaciated bodies, eating disorders characterized by dietary restriction or weight loss can — and do — occur at any weight. However, precisely because anorexia nervosa is associated with underweight, doctors are less likely to identify eating disorders among individuals who are in the so-called “normal” or above normal weight range, even if they have........ Read more »

  • July 31, 2014
  • 07:10 PM
  • 798 views

Twitter Psychosis as a Cultural Artifact

by The Neurocritic in The Neurocritic

The creation of the category “Twitter Psychosis" tells us more about the culture of contemporary psychiatry than it does about the purported dangers of social media overuse. Can Twitter really “cause” psychotic symptoms in predisposed individuals? Or is Twitter merely the latest technical innovation that influences “the form, origin and content of delusional beliefs” (Bell et al., 2005)? Twitter as the new telephone tower, radio waves, microchip implant or personal TV show, if you wil........ Read more »

Kalbitzer J, Mell T, Bermpohl F, Rapp MA, & Heinz A. (2014) Twitter Psychosis: A Rare Variation or a Distinct Syndrome?. The Journal of nervous and mental disease, 202(8), 623. PMID: 25075647  

  • July 30, 2014
  • 11:24 AM
  • 1,018 views

Violent Death Rates Increased After Traumatic Brain Injury

by William Yates, M.D. in Brain Posts

Anecdotal reports have linked traumatic brain injury with later violent death including death by suicide.Few large epidemiological studies have been published on this association.However, a recent Swedish population study published in JAMA Psychiatry provides valuable insight into this issue.Seena Fazel and colleagues from the University of Oxford, University College London and the Karolinksa Institute examined a large database of over 200,000 patients with TBI.Cases of TBI were identified from ........ Read more »

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